Nav1.8 inhibitor 42

Chemical Structure : Nav1.8 inhibitor 42

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货号: PC-23587Not For Human Use, Lab Use Only.

Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Nav1.8 inhibitor 42 is a potent, selective Nav1.8 inhibitor with IC50 of 35 nM (human Nav1.8), shows weak actiivty against mouse Nav1.8 (IC50=3040 nM).
Nav1.8 inhibitor 42 shows no activity against a broad panel of GPCRs, enzymes, and other ion channels.

物理化学性质&存储条件

分子量	521.41
分子式	C21H14F7N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluoro-2-(trifluoromethyl)phenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide

参考文献

1. Poslusney M, et al. Bioorg Med Chem Lett. 2024 Dec 5:130059.