Nav1.7 inhibitor WN2-R

Chemical Structure : Nav1.7 inhibitor WN2-R

加入收藏

货号: PC-24050Not For Human Use, Lab Use Only.

Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7.
WN2-R binds to the intended VSDIV pocket of Nv1.7.
WN2-R (10 uM) completely inhibits the native Na+ current while having almost no effect on the native K+ and Ca2+ currents in DRG neurons.
WN2-R exhibits impressive analgesic effects in acute and chronic inflammatory pain, as well as neuropathic pain models in mice.

物理化学性质&存储条件

分子量	457.59
分子式	C29H32FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-(dimethylamino)ethyl)-3-(4-fluorophenyl)-3-(1-(4-methylbenzyl)-1H-indol-3-yl)propanamide

参考文献

1. Wang G, et al. Research (Wash D C). 2025 Jan 29;8:0599.