| Cat. No. |
Product Name |
Information |
| PC-22424 |
ANP-230
Nav1.7/1.8/1.9 inhibitor
|
ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels. |
| PC-21779 |
XPC-5462
NaV1.2/1.6 inhibitor
|
XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively. |
| PC-21778 |
XPC-7224
NaV1.6 inhibitor
|
XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel. |
| PC-21678 |
LTGO-33
NaV1.8 inhibitor
|
LTGO-33 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.8 with IC50 of 44 nM (hNaV1.8), 600-fold selectivity against NaV1.1-NaV1.7 and NaV1.9. |
| PC-20850 |
DS43260857
NaV1.7 inhibitor
|
DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively. |
| PC-49611 |
A-887826
Nav 1.8 inhibitor
|
A-887826 (A 887826) is a potent and voltage-dependent Na(v)1.8 sodium channel blocker with IC50 of 11 nM (hNav1.8), potently blocks tetrodotoxin-resistant sodium (TTX-R Na(+)) currents (IC50=8 nM) from small diameter rat DRG neurons. |
| PC-49224 |
AM-0466
NaV1.7 inhibitor
|
AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM). |
| PC-47037 |
QX-314 bromide
Sodium channel inhibitor
|
QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons. |
| PC-47036 |
QX-314 chloride
Sodium channel blocker
|
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons. |
| PC-47030 |
BW-031 iodide
Nav1.7 inhibitor
|
BW-031 iodide is a potent cationic sodium channel inhibitor, inhibited Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314. |
| PC-47029 |
BW-031 chloride
Nav1.7 inhibitor
|
BW-031 chloride is a potent cationic sodium channel inhibitor, inhibits Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314. |
| PC-38662 |
ABBV-318
Nav1.7/ Nav1.8 blocker
|
ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively. |
