XPC-7224 | NaV1.6 inhibitor | Probechem Biochemicals

Chemical Structure : XPC-7224

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XPC-7224 (XPC7224)

货号: PC-21778Not For Human Use, Lab Use Only.

XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.

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生物&药学活性

XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.
XPC-7224 is >100-fold more potent than all other NaV subtypes.
XPC-7224 (500 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons.
NaV1.6 R1626A displays a > 1000-fold drop in potency for XPC-7224.

物理化学性质&存储条件

分子量	483.61
分子式	C25H30FN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-fluoro-5-methyl-4-(methyl(1-(1-phenylethyl)piperidin-4-yl)amino)-N-(pyrimidin-2-yl)benzenesulfonamide

参考文献

1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.

XPC-7224 (XPC7224)

生物&药学活性

物理化学性质&存储条件

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XPC-7224 (XPC7224)

生物&药学活性

物理化学性质&存储条件

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