ANP-230 (DSP-2230) | Nav1.7/1.8/1.9 inhibitor | Probechem Biochemicals

Chemical Structure : ANP-230

CAS No.: 1233231-30-5

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ANP-230 (DSP-2230, DSP2230)

货号: PC-22424Not For Human Use, Lab Use Only.

ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels.

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生物&药学活性

ANP-230 (DSP-2230) is a selective sodium channel blocker of human Nav1.7, Nav1.8, and Nav1.9 with IC50 of 7.1, 11.4, and 6.7 μM (sodium currents), shows only low inhibitory activity to human cardiac Nav1.5 channel and rat central Nav channels.
ANP-230 shows comparable potency and selectivity when evaluated by manual patch-clamp technique (IC50 values for Nav1.7, Nav1.8, and Nav1.5 were 9.3, 5.5, and 151.2 μM, respectively.
ANP-230 causes a depolarizing shift of the activation curve for peripheral Nav channels and decelerates the gating kinetics of Nav1.7.
ANP-230 (10, 30 uM) potently reduces neuronal excitability in rat DRG neurons.

物理化学性质&存储条件

分子量	419.41
分子式	C20H20F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(((3-Cyclobutyl-5-(3,4,5-trifluorophenoxy)-3H-imidazo[4,5-b]pyridin-2-yl)methyl)amino)propanamide

参考文献

1. Kamei T, et al. Biochem Biophys Res Commun. 2024 May 14;721:150126.

ANP-230 (DSP-2230, DSP2230)

生物&药学活性

物理化学性质&存储条件

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ANP-230 (DSP-2230, DSP2230)

生物&药学活性

物理化学性质&存储条件

参考文献

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