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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-XPC-5462
XPC-5462

Chemical Structure : XPC-5462

CAS No.: 2230145-14-7

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XPC-5462 (XPC5462)

货号: PC-21779Not For Human Use, Lab Use Only.

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.
XPC-5462 displays weak activity against NaV1.7, and no significant effect on other NaV subtypes.
XPC-7224 (150 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons. XPC-7224 inhibits neocortical ex vivo seizure-like events.

物理化学性质&存储条件

分子量 486.50
分子式 C20H18F4N4O2S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide

参考文献

1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.

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