AM-0466 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : AM-0466

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AM-0466 (AM0466)

货号: PC-49224Not For Human Use, Lab Use Only.

AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM).

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生物&药学活性

AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM).
AM-0464 demonstrates robust pharmacodynamic activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect in open-field activity.

物理化学性质&存储条件

分子量	552.528
分子式	C27H19F3N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-methoxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-oxo-N-(pyrimidin-2-yl)-1,2-dihydroquinoline-6-sulfonamide

参考文献

1. Russell F Graceffa, et al. J Med Chem. 2017 Jul 27;60(14):5990-6017.

AM-0466 (AM0466)

生物&药学活性

物理化学性质&存储条件

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AM-0466 (AM0466)

生物&药学活性

物理化学性质&存储条件

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