| Cat. No. |
Product Name |
Information |
| PC-45625 |
Nav1.7-IN-2
NaV1.7 inhibitor
|
Nav1.7-IN-2 is a potent, selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50=80 nM), extracts from patent WO/2011103196 A1, compound example J. |
| PC-45224 |
Ranolazine dihydrochloride
Sodium channel inhibitor
|
Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models. |
| PC-42318 |
ETH2120
Sodium ionophore
|
ETH2120 is a sodium ionophore, relieves hydrogen-dependent caffeate reduction and completely abolishes ATP synthesis in cells. |
| PC-42201 |
Nicainoprol
Sodium channels inhibitor
|
A sodium channels blocker, adrenergic receptor antagonist and class 1 antiarrhythmic agent.. |
| PC-45079 |
ICA-121431
Nav1.3/Nav1.1 inhibitor
|
ICA-121431 is a potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM. |
| PC-45762 |
XEN-907
NaV1.7 inhibitor
|
XEN-907 (XEN907) is a potent, selective NaV1.7 blocker with IC50 of 3 nM. |
| PC-42804 |
A-803467
Nav1.8 inhibitor
|
A-803467 (A803467) potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM. |
| PC-45068 |
Eleclazine hydrochloride
I(Na,late) inhibitor
|
Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-45252 |
Flecainide acetate
Nav1.5 inhibitor, RyR2 inhibitor
|
A class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
| PC-26899 |
ICA604025
Nav1.9 inhibitor
|
ICA604025 is a potent, selective sodium channel Nav1.9 subtype inhibitor, inhibits human Nav1.9 in a state dependent manner with EC50s of 9 nM and 1.1 μM for the activated/inactivated state versus resting closed state. |
| PC-26654 |
ZL141
GSK3β/Nav1.6 inhibitor
|
ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM. |
| PC-26525 |
S3226
NHE3 inhibitor
|
S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2. |
