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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-Ranolazine dihydrochloride
Ranolazine dihydrochloride

Chemical Structure : Ranolazine dihydrochloride

CAS No.: 95635-56-6

Ranolazine dihydrochloride (RS-43285, CVT 303)

货号: PC-45224Not For Human Use, Lab Use Only.

Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.
Ranolazine dihydrochloride also inhibits cardiac sodium channel Nav1.5, shows antiarrhythmic, antiepileptic, and analgesic effects.

物理化学性质&存储条件

分子量 500.4584
分子式 C24H35Cl2N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2)

参考文献

1. Sokolov S, et al. Front Pharmacol. 2013 Jun 21;4:78.

2. Noble D, et al. Heart. 2006 Jul;92 Suppl 4:iv1-iv5.

3. Wang WQ, et al. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.

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