AnCoA4 |CAS:24211-36-7 Probechem Biochemicals

Chemical Structure : AnCoA4

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AnCoA4 (AnCoA-4;Jamaicin)

货号: PC-60194Not For Human Use, Lab Use Only.

AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

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1 g		Get quote

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生物&药学活性

AnCoA4 (AnCoA-4, Jamaicin) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.
AnCoA4 binds to the C terminus of Orai1, directly inhibits calcium influx through the channel and also reduces binding of STIM1.
AnCoA4 decreased gene expression involved in T cell activation, including IL2, CD27, NFATC1, TNF, TBX21, CSF, ICOS, and CXCR3.
AnCoA4 effectively blocks T cell activation in vitro and in vivo.

物理化学性质&存储条件

分子量	378.37
分子式	C22H18O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-methoxybenzo[d][1,3]dioxol-5-yl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one

参考文献

1. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-92.

2. Sadaghiani AM, et al. Chem Biol. 2014 Oct 23;21(10):1278-1292.

AnCoA4 (AnCoA-4;Jamaicin)

生物&药学活性

物理化学性质&存储条件

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AnCoA4 (AnCoA-4;Jamaicin)

生物&药学活性

物理化学性质&存储条件

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