ICA-121431 |CAS:313254-51-2 Probechem Biochemicals

Chemical Structure : ICA-121431

CAS No.: 313254-51-2

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ICA-121431 (ICA121431)

货号: PC-45079Not For Human Use, Lab Use Only.

A potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

ICA-121431 is a potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM.
ICA-121431 exhibits up to 1,000-fold selectivity over other TTX-sensitive or resistant (i.e., Nav1.5) sodium channels.
ICA-121431 also shows an intermediate sensitivity (IC50=240 nM) for Nav1.2.

物理化学性质&存储条件

分子量	449.5453
分子式	C23H19N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-

参考文献

1. McCormack K, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.

2. Osteen JD, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6836-6841.

ICA-121431 (ICA121431)

生物&药学活性

物理化学性质&存储条件

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ICA-121431 (ICA121431)

生物&药学活性

物理化学性质&存储条件

参考文献

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