| Cat. No. |
Product Name |
Information |
| PC-35117 |
VGSC blocker 1
Nav1.5 inhibitor
|
VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM. |
| PC-35103 |
GNE-131
NaV1.7 inhibitor
|
GNE-131 is a potent, selective inhibitor of sodium channel NaV1.7 with IC50 of 3 nM, >80-fold selectivity over the cardiac sodium channel NaV1.5. |
| PC-35086 |
PF-06869206
NaPi2a inhibitor
|
PF-06869206 (PF06869206) is a novel potent, selective, orally bioavailable inhibitor of Sodium-Phosphate Cotransporter NaPi2a (SLC34A1) with IC50 of 380 nM. |
| PC-35055 |
Rimeporide
NHE1 inhibitor
|
Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure. |
| PC-35054 |
KR-32570
NHE1 inhibitor
|
KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM. |
| PC-35053 |
KR-33028
NHE1 inhibitor
|
KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM. |
| PC-35052 |
Cariporide
NHE1 inhibitor
|
Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM). |
| PC-35034 |
BI-9627
NHE1 inhibitor
|
BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. |
| PC-63534 |
SPX-101
ENaC inhibitor
|
SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits. |
| PC-63263 |
GpTx-1
NaV1.7 inhibitor
|
GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.. |
| PC-43216 |
CNV1014802 hydrochloride
NaV1.7 inhibitor
|
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.. |
| PC-43215 |
CNV1014802
Nav1.7 inhibitor
|
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo. |
