BI-8668 |CAS:2084059-97-0 Probechem Biochemicals

Chemical Structure : BI-8668

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BI-8668 (BI 8668)

货号: PC-38297Not For Human Use, Lab Use Only.

BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay).

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生物&药学活性

BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay).
BI-8668 inhibits ENaC-mediated water permeability through cell monolayers of the cell line M-1 (M-1 cells: mouse kidney tubules cells) with 81% inhibition at 3 uM.

物理化学性质&存储条件

分子量	523.463
分子式	C23H32Cl2N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-amino-6-chloropyrazine-2-carboxamido)methyl)-6-((2-(dimethylamino)ethyl)(methyl)carbamoyl)-1,3-diethyl-1H-benzo[d]imidazol-3-ium chloride

参考文献

1. Betzemeier B, et al. Eur J Med Chem. 2023 Dec 18;265:116038.

BI-8668 (BI 8668)

生物&药学活性

物理化学性质&存储条件

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BI-8668 (BI 8668)

生物&药学活性

物理化学性质&存储条件

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