| Cat. No. |
Product Name |
Information |
| PC-62647 |
Diminazene aceturate
ASIC1a inhibitor
|
Diminazene aceturate is an anti-infective agent, also is a slow pore blocker of acid-sensing ion channel 1a (ASIC1a) with IC50 of 0.3 uM. |
| PC-62325 |
GNE-0439
Nav1.7 inhibitor
|
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM). |
| PC-62324 |
GX-936
NaV1.7 inhibitor
|
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM. |
| PC-62323 |
GX-674
Nav1.7 inhibitor
|
GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM. |
| PC-61870 |
PF-04531083
Nav1.8 inhibitor
|
PF-04531083 (PF 4531083) is a potent and selective, orally available sodium channel Nav1.8 blocker for treatment of pain. |
| PC-61869 |
XEN-402
|
XEN-402 (Funapide,TV-45070) is a potent and selective, orally available sodium channel Nav1.7 and Nav1.8 blocker for treatment of pain. |
| PC-61857 |
PF-05241328
NaV1.7 inhibitor
|
PF-05241328 (PF 5241328) is a potent and selective, orally active inhibitor of voltage-dependent sodium channel Nav1.7 with IC50 of 31 nM. |
| PC-61854 |
AZD-3161
NaV1.7 inhibitor
|
AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5. |
| PC-61853 |
PF-04856264
NaV1.7 inhibitor
|
PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5. |
| PC-61336 |
Lacosamide
Sodium channel inhibitor
|
Lacosamide (SPM 927) is an anticonvulsant compound that enhances the slow inactivation of voltage-gated sodium channels without affecting the fast inactivation of voltage-gated sodium channels. |
| PC-60629 |
AMG 8379
NaV1.7 inhibitor
|
AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM. |
| PC-70213 |
Flecainide
Nav1.5 inhibitor, RyR2 inhibitor
|
Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential. |
