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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-CNV1014802 hydrochloride
CNV1014802 hydrochloride

Chemical Structure : CNV1014802 hydrochloride

CAS No.: 934240-31-0

CNV1014802 hydrochloride (GSK-1014802 hydrochloride;CNV-1014802 hydrochloride;Raxatrigine hydrochloride;Vixotrigine)

货号: PC-43216Not For Human Use, Lab Use Only.

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.

物理化学性质&存储条件

分子量 350.815
分子式 C18H20ClFN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, hydrochloride (1:1), (2S,5R)-

参考文献

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.

2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.

3. Zakrzewska JM, et al. Lancet Neurol. 2017 Apr;16(4):291-300.

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