AZD-1305 |CAS:872045-91-5 Probechem Biochemicals

Chemical Structure : AZD-1305

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AZD-1305 (AZD1305)

货号: PC-63154Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

AZD-1305 is a novel antiarrhythmic agent that predominantly blocks the rapid component of IKr, the L-type calcium current, and the inward sodium current in mammalian cells and ventricular cardiomyocytes。
AZD-1305 significantly prolongs action potential duration and reduces excitability at 0.1-10 uM in dogs.
AZD-1305 effectively prevents induction of persistent acetylcholine-mediated atrial fibrillation (AF) in vivo.

物理化学性质&存储条件

分子量	434.512
分子式	C22H31FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(7-(2-(4-Cyano-2-fluorophenoxy)ethyl)-9-oxa-3,7-diazabicyclo(3.3.1)non-3-yl)ethyl)carbamic acid tert-butyl ester

参考文献

1. Sicouri S, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):255-9.

2. Burashnikov A, et al. J Cardiovasc Pharmacol. 2010 Jul;56(1):80-90.

3. Johnson DM, et al. Circ Arrhythm Electrophysiol. 2012 Feb;5(1):201-9.

4. Geller JC, et al. J Clin Pharmacol. 2009 Mar;49(3):312-22.

AZD-1305 (AZD1305)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD-1305 (AZD1305)

生物&药学活性

物理化学性质&存储条件

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