PF-05198007 |CAS:1235406-19-5 Probechem Biochemicals

Chemical Structure : PF-05198007

CAS No.: 1235406-19-5

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PF-05198007 (PF05198007)

货号: PC-63175Not For Human Use, Lab Use Only.

PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM).

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, with no significant activity against Nav1.5 (IC50>10 uM).
PF-05198007 increases action potential rheobase in small diameter mDRG neurons, demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.

物理化学性质&存储条件

分子量	533.901
分子式	C19H12ClF4N5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(3-amino-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide

参考文献

1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042.

2. Alexandrou AJ, et al. PLoS One. 2016 Apr 6;11(4):e0152405.

PF-05198007 (PF05198007)

生物&药学活性

物理化学性质&存储条件

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PF-05198007 (PF05198007)

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