Tetrodotoxin |CAS:4368-28-9 Probechem Biochemicals

Chemical Structure : Tetrodotoxin

CAS No.: 4368-28-9

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Tetrodotoxin (TTx)

货号: PC-43094Not For Human Use, Lab Use Only.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.

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生物&药学活性

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
Tetrodotoxin-sensitive sodium channel (Nav) family include Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant.
Tetrodotoxin (TTx) inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.

物理化学性质&存储条件

分子量	319.268
分子式	C11H17N3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-

参考文献

1. Rogers M, et al. Assay Drug Dev Technol. 2016 Mar;14(2):109-30.

2. Frelin C, et al. J Biol Chem. 1983 Jun 25;258(12):7256-9.

3. Reiser G, et al. Brain Res. 1983 Feb 21;261(2):335-40.

Tetrodotoxin (TTx)

生物&药学活性

物理化学性质&存储条件

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Tetrodotoxin (TTx)

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