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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-CNV1014802
CNV1014802

Chemical Structure : CNV1014802

CAS No.: 934240-30-9

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CNV1014802 (GSK-1014802;CNV-1014802;Raxatrigine;Vixotrigine;BIIB074)

货号: PC-43215Not For Human Use, Lab Use Only.

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.

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10 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.

Pain

Phase 2 Clinical

物理化学性质&存储条件

分子量 314.3541
分子式 C18H19FN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, (2S,5R)-

参考文献

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.

2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.

3. Zakrzewska JM, et al. Lancet Neurol. 2017 Apr;16(4):291-300.

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