DA-0218 | Nav1.7 inhibitor | Probechem Biochemicals

Chemical Structure : DA-0218

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DA-0218 (DA0218)

货号: PC-72205Not For Human Use, Lab Use Only.

DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.

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生物&药学活性

DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.
DA-0218 has no effect on sodium currents in Nav1.5-transfected human embryonic kidney 293 cells in patch-clamp experiments.
DA-0218 shows analgesic activity predominantly in phase II in formalin-induced inflammatory pain mouse model.
DA-0218 produced acute reduction in paclitaxel-induced mechanical allodynia, and inhibited histamine-induced acute itch and lymphoma-induced chronic itch.

物理化学性质&存储条件

分子量	543.711
分子式	C36H37N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-benzyl-1H-indol-3-yl)-3-(3-phenoxyphenyl)-N-(2-(pyrrolidin-1-yl)ethyl)propanamide

参考文献

1. Sharat Chandra, et al. Anesthesiology. 2020 Sep;133(3):611-627.

DA-0218 (DA0218)

生物&药学活性

物理化学性质&存储条件

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DA-0218 (DA0218)

生物&药学活性

物理化学性质&存储条件

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