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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-Flecainide
Flecainide

Chemical Structure : Flecainide

CAS No.: 54143-55-4

Flecainide (R818)

货号: PC-70213Not For Human Use, Lab Use Only.

Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias, works by blocking the Nav1.5 sodium channel in the heart, slowing the upstroke of the cardiac action potential.
Flecainide also inhibits ryanodine receptor 2 (RyR2), reduces calcium sparks and thus arrhythmogenic calcium waves in the heart.

物理化学性质&存储条件

分子量 414.343
分子式 C17H20F6N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

参考文献

1. Hilliard FA, et al. J Mol Cell Cardiol. 2010 Feb;48(2):293-301.

2. Salvage SC, et al. Acta Physiol (Oxf). 2015 Jul;214(3):361-75.

3. Salvage SC, et al. Br J Pharmacol. 2017 Apr 3. doi: 10.1111/bph.13807.

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