DS43260857 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : DS43260857

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DS43260857 (DS 43260857)

货号: PC-20850Not For Human Use, Lab Use Only.

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.

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生物&药学活性

DS43260857 is a potent, selective NaV1.7 inhibitor with IC50 of 15 nM (hNaV1.7), shows 440-fold and 930-fold selectivity over hNaV1.1 and hNaV1.5, respectively.
DS43260857 potently inhibits mouse NaV1.7 (mNaV1.7) with IC50 of 61 nM.
DS43260857 demonstrates highly potent in vitro activities against human and mouse NaV1.7 with an excellent PK profile and demonstrated potent in vivo efficacy in PSL mice at 1 mg/kg.

物理化学性质&存储条件

分子量	423.41
分子式	C19H16F3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NS(C1CC1)(=O)=O)C2=CC=C(N(C3=CC(C(F)(F)F)=CN=C3)C=C4C)C4=C2

参考文献

1. Narayan Karanjule, et al. ACS Med. Chem. Lett. 2023.

DS43260857 (DS 43260857)

生物&药学活性

物理化学性质&存储条件

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DS43260857 (DS 43260857)

生物&药学活性

物理化学性质&存储条件

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