ETD001 | ENaC inhibitor | Probechem Biochemicals

Chemical Structure : ETD001

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ETD001 (ETD-001)

货号: PC-23462Not For Human Use, Lab Use Only.

ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM.

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生物&药学活性

ETD001 is a potent, selective epithelial sodium channel (ENaC) inhibitor with IC50 of 57 nM.
ETD001 is an inhibitor of sheep ENaC with IC50 of 30.5 nM.
ETD001 shows no significant effects against hERG, CaV1.2, NaV1.5 and Kv1.5 up to 30 uM.
ETD001 prolonged retention in the airways of rats (13 % of the delivered dose retained after 6h) following intratracheal administration and a potent and long-acting effect in a sheep model of mucociliary clearance following inhalation (ED100 (4–6h) = 9 μg/kg).

物理化学性质&存储条件

分子量	1045.94
分子式	C41H57F6N9O16
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Glucitol, 1,1′-[[1-[[2-[[[(3-amino-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbonyl]amino]methyl]-1,3-diethyl-1H-benzimidazolium-5-yl]carbonyl]-4-piperidinyl]imino]bis[1-deoxy-, 2,2,2-trifluoroacetate, 2,2,2-trifluoroacetate (1:1:1)

参考文献

1. Danahay H, et al. Eur J Med Chem. 2024 Nov 8;282:117040.

ETD001 (ETD-001)

生物&药学活性

物理化学性质&存储条件

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ETD001 (ETD-001)

生物&药学活性

物理化学性质&存储条件

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