GX-936 |CAS:1235406-09-3 Probechem Biochemicals

Chemical Structure : GX-936

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GX-936 (GX936;PF 05196233)

货号: PC-62324Not For Human Use, Lab Use Only.

GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM.

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生物&药学活性

GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM.
GX-936 inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.

物理化学性质&存储条件

分子量	575.585
分子式	C24H20F3N7O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyano-4-[2-[1-(1-ethyl-3-azetidinyl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide

参考文献

1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464.

2. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801.

GX-936 (GX936;PF 05196233)

生物&药学活性

物理化学性质&存储条件

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GX-936 (GX936;PF 05196233)

生物&药学活性

物理化学性质&存储条件

参考文献

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