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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-GX-674
GX-674

Chemical Structure : GX-674

CAS No.: 1432913-36-4

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GX-674 (GX674)

货号: PC-62323Not For Human Use, Lab Use Only.

GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
    GX-674 inhibits Nav1.7 with much higher potency than most other Nav isoforms: Nav1.7 ~ Nav1.2 > Nav1.6 >>Nav1.1 > Nav1.8 > Nav1.3 > Nav1.4 ~ Nav1.5, and 100,000 times greater than that of the cardiac isoform Nav1.5.

    物理化学性质&存储条件

    分子量 534.941
    分子式 C21H13ClF2N6O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(2-Amino-1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

    参考文献

    1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464.

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