AZD-3161 |CAS:1369501-46-1 Probechem Biochemicals

Chemical Structure : AZD-3161

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AZD-3161 (AZD3161)

货号: PC-61854Not For Human Use, Lab Use Only.

AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.

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生物&药学活性

AZD-3161 (AZD3161) is a potent and selective sodium channel Nav1.7 blocker with pIC50 of 7.1, >100-fold selective over NaV1.5.
AZD-3161 shows high NaV1.7 potency and selectivity versus NaV1.5 and hERG, low lipophilicity, good solubility and high in vitro metabolic stability.
AZD-3161 shows in vivo efficacy in a nociceptive pain model.

物理化学性质&存储条件

分子量	459.56
分子式	C26H25N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((methylsulfonyl)amino)-2-phenyl-N-((1S)-1-phenylpropyl)-4-quinolinecarboxamide

参考文献

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
2. Kers I, et, al. Bioorg Med Chem Lett. 2012 Sep 1; 22(17): 5618-24.

AZD-3161 (AZD3161)

生物&药学活性

物理化学性质&存储条件

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AZD-3161 (AZD3161)

生物&药学活性

物理化学性质&存储条件

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