| Cat. No. |
Product Name |
Information |
| PC-62378 |
InS3-54
STAT3 inhibitor
|
InS3-54 is a small molecule STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3. |
| PC-62377 |
InS3-54A18
STAT3 inhibitor
|
InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties. |
| PC-62347 |
S3I-M2001
STAT3 inhibitor
|
S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers. |
| PC-61669 |
FLLL31
STAT3 inhibitor
|
FLLL31 (Tetramethylcurcumin) is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells. |
| PC-61668 |
FLLL32
STAT3 inhibitor
|
FLLL32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM). |
| PC-61667 |
XZH-5
STAT3 inhibitor
|
XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes. |
| PC-61666 |
SD-1029
STAT3 inhibitor
|
SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells. |
| PC-61660 |
LLL3
STAT3 inhibitor
|
LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities. |
| PC-61629 |
Capstafin
STAT5b inhibitor
|
Capstafin is a phosphorylation of capsaicinoid derivative that acts as a highly potent, selective inhibitor of STAT5b with Ki of 0.34 uM. |
| PC-61628 |
STAT5b inhibitor 7
STAT5b inhibitor
|
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM. |
| PC-61476 |
SC99
STAT3 inhibitor
|
SC99 is a novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src. |
| PC-61312 |
IQDMA
STAT3/5 inhibitor
|
IQDMA is a cell-permeable, small molecule inhibitor of the transcription factor STAT5, and dual STAT3/5 degrader (IC50=0.54-1.63 μM). |
