HP590 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : HP590

CAS No.: 2971855-37-3

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HP590 (HP 590)

货号: PC-20357Not For Human Use, Lab Use Only.

HP590 is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

HP590 (HP 590) is a highly potent, and orally bioavailable STAT3 inhibitor with IC50 of 27.8 nM, inibits IL-6 induced of the p-STAT3 Tyr705 and p-Ser727 activation in GC cells with lower nanomolar inhibitory activity.
HP590 selectively targets STAT3 to remarkably inhibit its canonical and noncanonical activation and corresponding biological functions, thereby resulting in the growth inhibition of gastric cancer in vitro and in vivo.

物理化学性质&存储条件

分子量	590.53
分子式	C29H24F6N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(4-(2,2,2-trifluoroethoxy)benzyl)piperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenyl)methanone

参考文献

1. Peng He, et al. J Med Chem. 2022 Oct 13;65(19):12650-12674.

HP590 (HP 590)

生物&药学活性

物理化学性质&存储条件

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HP590 (HP 590)

生物&药学活性

物理化学性质&存储条件

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