K1836 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : K1836

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K1836 (STAT3 inhibitor K1836)

货号: PC-20120Not For Human Use, Lab Use Only.

K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation.

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生物&药学活性

K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling, blocks STAT3 phosphorylation.

K1836 inhibits critical components of senescence-associated secretory phenotype (SASP), including IL-6, GROα and MCP-1 production, which could theoretically modify the tumour microenvironment and interactions of tumour cells with the immune system.

K1836 is able to modify the SASP by blocking secretion of pro-tumourigenic cytokines, including IL-6.

物理化学性质&存储条件

分子量	325.34
分子式	C16H11N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,1-dioxidobenzo[b]thiophen-6-yl)-1H-pyrrolo[2,3-b]pyridine-4-carboxamide

参考文献

1. Romana Mikyskova, et al. Mol Med Rep. 2023 Apr;27(4):81.

K1836 (STAT3 inhibitor K1836)

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物理化学性质&存储条件

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K1836 (STAT3 inhibitor K1836)

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物理化学性质&存储条件

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