| Cat. No. |
Product Name |
Information |
| PC-23165 |
K2071
STAT3 inhibitor
|
K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines. |
| PC-22565 |
Fludarabine
STAT1 inhibitor, NAT10 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
| PC-21893 |
Stattic
STAT3 inhibitor
|
Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro. |
| PC-21874 |
WZ-2-033
STAT3 inhibitor
|
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling. |
| PC-20934 |
WB737
STAT3 inhibitor
|
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM. |
| PC-20636 |
MNS1-Leu
STAT3 inhibitor
|
MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20635 |
MNS1-MV
STAT3 inhibitor
|
MNS1-MV is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells. |
| PC-20634 |
IST5-002
Stat5 inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
| PC-20632 |
STAT3 inhibitor LY5
STAT3 inhibitor
|
STAT3 inhibitor LY5 is a specfic STAT3 small molecule inhibitor, binds to STAT3 SH2 domain wioth Kd of 2.5 uM. |
| PC-20631 |
BP-1-108
STAT5 inhibitor
|
BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively). |
| PC-20627 |
W2014-S
STAT3 inhibitor
|
W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling. |
