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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Stattic
Stattic

Chemical Structure : Stattic

CAS No.: 19983-44-9

Stattic

货号: PC-21893Not For Human Use, Lab Use Only.

Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Stattic is a potent, selective nonpeptidic STAT3 inhibitor, inhibits the function of the STAT3 SH2 domain (IC50=5.1 uM) regardless of the STAT3 activation state in vitro.
Stattic selectively inhibits activation, dimerization, and nuclear translocation of STAT3 and increases the apoptotic rate of STAT3-dependent breast cancer cell lines.
Stattic inhibits STAT3 phosphorylation (at Y705 and S727).
Stattic is a useful tool for the inhibition of STAT3 in cell lines or animal tumor models displaying constitutive STAT3 activation.

物理化学性质&存储条件

分子量 211.19
分子式 C8H5NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Nitrobenzo[b]thiophene 1,1-dioxide

参考文献

1. John S McMurray, et al. Chem Biol. 2006 Nov;13(11):1123-4.

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