IST5-002 | Stat5a/b inhibitor | Probechem Biochemicals

Chemical Structure : IST5-002

CAS No.: 13484-66-7

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IST5-002 (Inhibitor of Stat5-002, N6-Benzyladenosine-5'-phosphate)

货号: PC-20634Not For Human Use, Lab Use Only.

IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells.

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5 mg	￥5880	In stock
10 mg	￥8980	In stock
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生物&药学活性

IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells.
IST5-002 blocks Bcr-Abl-induced Stat5a/b phosphorylation at 5 μM in Bcr-Abl-positive K562 cells.
IST5-002 blocks phosphorylation of Stat5a/b (CWR22Rv1, IC50=22 μM; HC-11, IC50=12 μM; T47D, IC50=24.8 μM), while total Stat5a/b levels remains unaffected.
IST5-002 shows no specific inhibition of other kinases in a panel of 50 kinases, does not block transcriptional activity of Stat3.
IST5-002 suppresses downstream signaling events and target gene expression induced by Stat5a/b in PC and CML cells.
IST5-002 suppresses Stat5a/b-mediated growth of PC through induction of apoptosis in experimental models of PC in vitro, in vivo and ex vivo.

物理化学性质&存储条件

分子量	437.34
分子式	C17H20N5O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

参考文献

1. Liao Z, et al. Mol Cancer Ther. 2015 Aug;14(8):1777-93.

IST5-002 (Inhibitor of Stat5-002, N6-Benzyladenosine-5'-phosphate)

生物&药学活性

物理化学性质&存储条件

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IST5-002 (Inhibitor of Stat5-002, N6-Benzyladenosine-5'-phosphate)

生物&药学活性

物理化学性质&存储条件

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