Fludarabine | STAT1 inhibitor, NAT10 inhibitor | Probechem Biochemicals

Chemical Structure : Fludarabine

CAS No.: 21679-14-1

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Fludarabine (F-ara-A, NSC 118218)

货号: PC-22565Not For Human Use, Lab Use Only.

Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.

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25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
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生物&药学活性

Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities.
Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
Fludarabine also inhibits N-acetyltransferase 10 (NAT10), shows anti-leukaemia effects both in vitro and in vivo.

物理化学性质&存储条件

分子量	285.24
分子式	C10H12FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

参考文献

1. Liang YB, et al. Mol Med Rep. 2017 Nov;16(5):6405-6411.

2. Sanhes L, et al. Leukemia. 2003 Jun;17(6):1104-11.

3. Frank DA, et al. Nat Med. 1999;5(4):444-447.

Fludarabine (F-ara-A, NSC 118218)

生物&药学活性

物理化学性质&存储条件

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Fludarabine (F-ara-A, NSC 118218)

生物&药学活性

物理化学性质&存储条件

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