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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-K2071
K2071

Chemical Structure : K2071

CAS No.: 3053609-54-1

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K2071 (K 2071)

货号: PC-23165Not For Human Use, Lab Use Only.

K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

K2071 is a potent, BBB penetrant STAT3 inhibitor, inhibits IL6-stimulated activity of STAT3 mediated byTyr705 phosphorylation, shows cytotoxicity against a set of human glioblastoma-derived cell lines.
K2071 is cytotoxic for glioblastoma cell lines. Human glioblastoma cell lines U-87 MG.
K2071 inhibits the growth of glioblastoma tumor spheroids.
Cytotoxic effect of K2071 is STAT3 inhibition-independent.
K2071 induces accumulation of mitotic cells. antimitotic activity arresting cells in prophase by altering mitotic spindle formation.
K2071 harbors a cytotoxic effect on TMZ-induced senescent glioblastoma U-87 MG cells and suppresses MCP-1 secretion.

物理化学性质&存储条件

分子量 301.36
分子式 C16H15NO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((4-methoxybenzyl)amino)benzo[b]thiophene 1,1-dioxide

参考文献

1. Patrik Oleksak, et al. ACS Pharmacol Transl Sci. 2024 Aug 12;7(9):2755-2783.

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