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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-WB737
WB737

Chemical Structure : WB737

CAS No.: 2591440-77-4

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WB737 (WB 737)

货号: PC-20934Not For Human Use, Lab Use Only.

WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM.
    WB737 selectively binds to STAT3 over STAT family proteins, including STAT1 and STAT2.
    WB737 effectively suppresses cell viability in the three STAT3 Mut NKTL cell lines (SNK6, YT, and NKYS) in a dose‐dependent manner, with limited effects on STAT3 WT cells.
    WB737 selectively inhibits the growth of STAT3Mut natural killer/T‐cell lymphoma (NKTL) cells by inducing apoptosis and blocking colony formation.
    WB737 selectively inhibits both canonical and noncanonical STAT3 signaling through suppression of pTyr705‐STAT3 and pSer727‐STAT3 in STAT3 Mut cells.
    WB737 (5 mg/kg for 14 days, oral gavage) induces almost complete tumor regression in STAT3Mut natural killer/T‐cell lymphoma (NKTL) in YT xenografts mice.

    物理化学性质&存储条件

    分子量 737.66
    分子式 C36H29F6N7O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-methyl-6-((5-(3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrazin-2-yl)oxy)-1H-indol-2-yl)(4-(4-(2,2,2-trifluoroethoxy)benzyl)piperazin-1-yl)methanone

    参考文献

    1. Yali Wang, et al. MedComm (2020). 2023 Jun 16;4(4):e284.

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