YY002 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : YY002

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YY002 (YY-002)

货号: PC-22095Not For Human Use, Lab Use Only.

YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation.

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生物&药学活性

YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation.
YY002 strongly suppresses STAT3 nuclear and mitochondrial functions in STAT3-dependent cells.
YY002 also shows no obvious inhibition on tyrosine kinases or serine kinases.
YY002 potently suppresses pancreatic cancer cells with high pSTAT3 (Tyr705 and Ser727) with IC50 of 3-11 nM.
YY002 inhibitscolony formation of multiple STAT3-dependent PDAC cells at concentration of 1 to 10 nM.
YY002 inhibits STAT3 Ser727 phosphorylation and mitochondrial OXPHOS.
YY002 (5 mg/kg/d to 20 mg/kg/d, oral) inhibits pancreatic cancer growth in PANC-1 tumor mouse xenograft models.

物理化学性质&存储条件

分子量	737.66
分子式	C36H29F6N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-methyl-6-((5-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrazin-2-yl)oxy)-1H-indol-2-yl)(4-(4-(2,2,2-trifluoroethoxy)benzyl)piperazin-1-yl)methanone

参考文献

1. Huang Chen, et al. ACS Cent Sci. 2024 Feb 10;10(3):579-594.

YY002 (YY-002)

生物&药学活性

物理化学性质&存储条件

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YY002 (YY-002)

生物&药学活性

物理化学性质&存储条件

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