MNS1-Leu

Chemical Structure : MNS1-Leu

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货号: PC-20636Not For Human Use, Lab Use Only.

MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.

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生物&药学活性

MNS1-Leu is a novel pyrazole-based small molecular inhibitor of STAT3 pathway, potently inhibit IL-6-induced STAT3 phosphorylation at 10 μM in dBT114 cells.
MNS1-Leu shows selective toxicity towards adult GBM and pediatric high grade glioma cells with IC50 values of 2.99 μM for MC-BT114 cells, 3.83 μM for MC-PED8 cells and 2.42 μM for SF7761.
MNS1-Leu (10 uM) effectively inhibits STAT3 activation and nuclear translocation in both adult GBM and pediatric HGG cells.
MNS1-Leu inhibits STAT3 activation via IL-6-mediated STAT3 pathway and not direct JAK2.
MNS1-Leu (0.5-2.5 uM) induces apoptosis and inhibit migration in adult GBM cells.
MNS1-Leu (10 mg/kg) slows pHGG growth in vivo and reduces STAT3 activation in pediatric HGG PDX model, with no toxicity and good stability in human plasma.

物理化学性质&存储条件

分子量	448.38
分子式	C20H22BrN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=S(C1=CC=C(N2N=C(CCC(C)C)C=C2C3=CC=C(Br)C=C3)C=C1)(N)=O

参考文献

1. Liang Zhang, et al. PLoS One. 2019 Jul 30;14(7):e0220569.

MNS1-Leu

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