| Cat. No. |
Product Name |
Information |
| PC-26586 |
STAT3-IN-12
STAT3 inhibitor
|
STAT3-IN-12 is a potent. selective STAT3 inhibitor, inhibits IL-6 induced JAK/STAT3 signalling pathway activation, inhibits cancer cell growth, migration, and induces cell apoptosis as well as cycle arrest. |
| PC-26446 |
ISS610
STAT3 inhibitor
|
ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1. |
| PC-26387 |
Magnesium isoglycyrrhizinate hydrate
STAT3 inhibitor
|
Magnesium isoglycyrrhizinate (MgIG) is a stereoisomer of glycyrrhizic acid with more potent hepatoprotective activity and less side effects than glycyrrhizic acid, inhibits inflammatory response through STAT3 pathway, also inhibits the activation of the LPS/TLRs/NF-κB signaling pathway in liver injury caused by anti-tuberculosis (anti-TB) drugs. |
| PC-26209 |
WP-1034
JAK-STAT inhibitor
|
WP-1034 is a small molecule JAK-STAT inhibitor, blocks Stat3 and Stat5 and induces caspase-dependent apoptosis in acute myeloid leukemia (AML). |
| PC-26022 |
WR-S-647
STAT3 inhibitor
|
WR-S-647 is a potent and specific inhibitor of STAT3 with binding affinity (SPR Kd) of 34 nM. |
| PC-25692 |
STAT6 ligand-1
STAT6 ligand
|
STAT6 ligand-1 is a specific ligand of STAT6 used for synthesizing STAT6 PROTAC degraders. |
| PC-25691 |
STAT6-IN-10
STAT6 inhibitor
|
STAT6-IN-10 is a potent, selective STAT6 inhibitor with IC50 of 1.2 uM in STAT6 reporter assay using STAT6-HEK293 cells. |
| PC-25690 |
STAT6-IN-9
STAT6 inhibitor
|
STAT6-IN-9 is a potent, selective STAT6 inhibitor with EC50 of 4 nM, efficiently blocks the STAT6 activation process mediated by the IL-13-IL-13 receptor/IL-4 receptor pathway, potently inhibits CCL17 secretion with IC50 of 4.6 nM. |
| PC-25689 |
STAT6-IN-7
STAT6 inhibitor
|
STAT6-IN-7 is a potent, selective STAT6 inhibitor with IC50 of 0.28 uM in STAT6 reporter assay using STAT6-HEK293 cells. |
| PC-25688 |
STAT6-IN-8
STAT6 inhibitor
|
STAT6-IN-8 is a potent, selective STAT6 inhibitor with IC50 of 0.25 uM in STAT6 reporter assay using STAT6-HEK293 cells. |
| PC-25480 |
Stafori-2
STAT4 inhibitor
|
Stafori-2 is the phosphate analog of Stafori-1 and potent, selective small molecule inhibitor of STAT4 Src homology 2 domain with Ki of 0.18 uM in FP assays, shows good selectivity over other STAT family members. |
| PC-25392 |
Colivelin TFA
STAT3 agonist
|
Colivelin TFA is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. |
