STAT3 CCD inhibitor K134

Chemical Structure : STAT3 CCD inhibitor K134

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货号: PC-28252Not For Human Use, Lab Use Only.

K134 is a specific STAT3 coiled-coil domain (CCD) inhibitor with binding Kd of 4.68 uM, attenuates LPS-induced acute lung injury (ALI) inflammation by targeting STAT3 phosphorylation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

K134 is a specific STAT3 coiled-coil domain (CCD) inhibitor with binding Kd of 4.68 uM, attenuates LPS-induced acute lung injury (ALI) inflammation by targeting STAT3 phosphorylation.
K134 inhibits activation and subsequent STAT3 phosphorylation in LPS-treated macrophages.
K134 (30 mg/kg) alleviated LPS-induced lung injury and blocked STAT3 phosphorylation in lung.
K134 decreased iNOS, pro-inflammatory cytokines, inflammatory cell infiltration and NO production of LPS-induced acute lung injury (ALI).

物理化学性质&存储条件

分子量	314.34
分子式	C17H18N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N'-(1-(2,4-dihydroxyphenyl)ethylidene)-2-(o-tolyloxy)acetohydrazide

参考文献

1. Yang S, et al. Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113523.