BP-1-102 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : BP-1-102

CAS No.: 1334493-07-0

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BP-1-102 (STAT3 inhibitor)

货号: PC-42174Not For Human Use, Lab Use Only.

BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM.
BP-1-102 blocks Stat3-pTyr peptide interactions and Stat3 activation at 4-6.8 uM, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells.
BP-1-102 suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and KLF8, blocks Stat3-NF-κB cross-talk, and enhances E-cadherin expression.
BP-1-102 inhibits growth of human breast and lung tumor xenografts.

物理化学性质&存储条件

分子量	626.5915
分子式	C29H27F5N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy-

参考文献

1. Zhang X, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8.

2. De Simone V, et al. Oncogene. 2015 Jul;34(27):3493-503.

3. Resetca D, et al. J Biol Chem. 2014 Nov 21;289(47):32538-47.

BP-1-102 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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BP-1-102 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

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