STAT compound (inhibitors, antagonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-23177	AK-068 STAT6 inhibitor	AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain.
PC-20633	TR120 STAT5 inhibitor	TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
PC-20630	SF-1-088 STAT5 inhibitor	SF-1-088 is a small molecule STAT5-SH2 domain inhibitor with Ki of 8.3 uM (Stat5b), shows no affinity for Stat1 and Stat3 (Ki>25 uM).
PC-20629	SF-1-066 STAT3 inhibitor	SF-1-066 is an orally bioavailable inhibitor of STAT3 with IC50 of 35 uM for inhibition of STAT3 DNA binding activity in vitro, binds to the STAT3 SH2 domain and inhibits STAT3 dimerization.
PC-20628	S3I-1757 STAT3 inhibitor	S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
PC-70276	OPB-51602	A novel small molecule SH2 domain-targeting STAT3 inhibitor with IC50/Kd of 7.3/5 nM.

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