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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Stafori-1
Stafori-1

Chemical Structure : Stafori-1

CAS No.:

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Stafori-1 (STAT four inhibitor-1)

货号: PC-24234Not For Human Use, Lab Use Only.

Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Stafori-1 is the first specific small-molecule inhibitor of STAT4, inhibits the protein-protein interaction domain of STAT4, the SH2 domain, with Ki of 1.7 uM, 10-70-fold selectivity over other STAT proteins.
Stafori-1 selectively stabilized STAT4 against thermaldenaturation in cell lysate.

物理化学性质&存储条件

分子量 322.24
分子式 C12H10F3O3PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(difluoro(2-fluoro-4-(5-methylthiophen-3-yl)phenyl)methyl)phosphonic acid

参考文献

1. Angew Chem Int Ed Engl. 2025 Mar 11:e202504420.

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