STAT3 inhibitor YZ-35

Chemical Structure : STAT3 inhibitor YZ-35

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货号: PC-24939Not For Human Use, Lab Use Only.

STAT3 inhibitor YZ-35 is potent, selective STAT3 inhibitor with binding Kd of 190 nM in ITC assays amd Ki of 380 nM in FP assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

STAT3 inhibitor YZ-35 is potent, selective STAT3 inhibitor with binding Kd of 190 nM in ITC assays amd Ki of 380 nM in FP assays.
YZ-35 directly binding to the SH2 domain.
YZ-35 demonstratessuperior inhibitory potency (IC50 = 0.63 μM) against MDA-MB-231 cells compared to juglone, Stattic, and TTI-101.
YZ-35 exhibits concentration- and time-dependent suppression of the phosphorylation of STAT3 at both Tyr705 and Ser727 residues in MDA-MB-231 and MCF-7 cell lines, while maintaining total STAT3 protein levels。
YZ-35 does not affect expression levels of STAT1 and STAT5 or inhibits their phosphorylation, also has no impact the phosphorylation of JAK2, Src, and ERK.
YZ-35 inhibits the expression of critical apoptosis-related proteins, including Cyclin D1, BCL-2, BCL-xL, and Survivin.
YZ-35 significantly inhibits the proliferation, migration, and promoted apoptosis of BRCA cells.
YZ-35 reduces tumor stemness in BRCA.
YZ-35 (5-10 mg/kg, i.v.) inhibits BRCA development on the xenograft model.

物理化学性质&存储条件

分子量	512.58
分子式	C29H24N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1H-Indol-2-yl)-N-((5-methoxy-3-((4-methoxyphenyl)thio)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl)acetamide

参考文献

1. Zhang Z, et al. J Med Chem. 2025 Jul 10. doi: 10.1021/acs.jmedchem.5c01301.