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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-AK-068
AK-068

Chemical Structure : AK-068

CAS No.: 2982851-09-0

AK-068 (AK068)

货号: PC-23177Not For Human Use, Lab Use Only.

AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

AK-068 is a highly potent, selective STAT6 ligand / inhibitor with Ki of 6 nM, binds to STAT6 SH2 domain.

物理化学性质&存储条件

分子量 663.67
分子式 C31H36F2N3O7PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

((2-(((S)-3,3-dimethyl-1-oxo-1-((S)-2-((R)-2-phenylmorpholine-4-carbonyl)pyrrolidin-1-yl)butan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid

参考文献

1. Kaneshige A, et al. J Med Chem. 2024 Sep 23. doi: 10.1021/acs.jmedchem.4c01009.

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