Napabucasin |CAS:83280-65-3 Probechem Biochemicals

Chemical Structure : Napabucasin

CAS No.: 83280-65-3

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Napabucasin (BBI-608, BBI608)

货号: PC-43790Not For Human Use, Lab Use Only.

Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).

规格	价格	库存
25 mg	￥1680	In stock
100 mg	￥3480	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Napabucasin (BBI-608) blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells.
Napabucasin (BBI-608) significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1).
Napabucasin (BBI-608) significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.

物理化学性质&存储条件

分子量	240.2109
分子式	C14H8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-

参考文献

1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.

2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8.

3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.

Napabucasin (BBI-608, BBI608)

生物&药学活性

物理化学性质&存储条件

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Napabucasin (BBI-608, BBI608)

生物&药学活性

物理化学性质&存储条件

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