FLLL12

Chemical Structure : FLLL12

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货号: PC-28218Not For Human Use, Lab Use Only.

FLLL12 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FLLL12 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity
FLLL12 inhibits cell viability in eight different breast and prostate cancer cell lines with IC50 of 0.3-3.8 uM.
FLLL12 inhibits AKT phosphorylation and downregulate the expression of HER2/neu.
FLLL12 inhibits phosphorylation of signal transducer and activator of transcription 3 (STAT3).
FLLL12 inhibits cancer cell growth and migration.
FLLL12 effectively inhibit STAT3, AKT, and HER2/neu pathways.

物理化学性质&存储条件

分子量	386.40
分子式	C21H22O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one

参考文献

1. Cen L, et al. BMC Cancer. 2009 Mar 30;9:99.

2. Friedman L, et al. Anticancer Drugs. 2009 Jul;20(6):444-9.

3. Lin L, et al. Cancer Sci. 2009 Sep;100(9):1719-27.

FLLL12

生物&药学活性

物理化学性质&存储条件

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FLLL12

生物&药学活性

物理化学性质&存储条件

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