HO-3867 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : HO-3867

CAS No.: 1172133-28-6

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HO-3867 (HO 3867, HO3867)

货号: PC-42160Not For Human Use, Lab Use Only.

HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.
HO-3867 induces G2-M cell cycle arrest in A2780 cells by modulating cell cycle regulatory molecules p53, p21, p27, CDK 2, and cyclin, and promotes apoptosis.
HO-3867 inhibits pSTAT3 (Tyr705 and Ser727) and JAK1 and increases apoptotic markers cleaved caspase-3 and PARP in xenograft tumor tissues.

物理化学性质&存储条件

分子量	464.5468
分子式	C28H30F2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	4-Piperidinone, 1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-, (3E,5E)-

参考文献

1. Rath KS, et al. Cancer Res. 2014 Apr 15;74(8):2316-27.

2. Selvendiran K, et al. Mol Cancer Ther. 2010 May;9(5):1169-79.

3. Selvendiran K, et al. Cancer Biol Ther. 2011 Nov 1;12(9):837-45.

HO-3867 (HO 3867, HO3867)

生物&药学活性

物理化学性质&存储条件

参考文献

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HO-3867 (HO 3867, HO3867)

生物&药学活性

物理化学性质&存储条件

参考文献

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