SH-4-54 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : SH-4-54

CAS No.: 1456632-40-8

加入收藏

SH-4-54 (STAT3 inhibitor)

货号: PC-45109Not For Human Use, Lab Use Only.

SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM.
SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.
SH-4-54 potently suppresses glioma tumor growth, and inhibits pSTAT3 in vivo.

物理化学性质&存储条件

分子量	610.5921
分子式	C29H27F5N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-

参考文献

1. Haftchenary S, et al. ACS Med Chem Lett. 2013 Sep 8;4(11):1102-7.

2. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.

3. Linher-Melville K, et al. PLoS One. 2016 Aug 11;11(8):e0161202.

SH-4-54 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SH-4-54 (STAT3 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.