Debio 0617B |CAS:1332329-27-7 Probechem Biochemicals

Chemical Structure : Debio 0617B

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Debio 0617B (Debio 0617B;Debio-0617B)

货号: PC-60417Not For Human Use, Lab Use Only.

Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM).

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生物&药学活性

Debio 0617B is a first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM).
Debio 0617B showes dose-dependent inhibition of pSTAT3 in STAT3-activated carcinoma cell lines (IC50=175 nM).
Debio 0617B also showes potent antiproliferative activity in a panel of cancer cell lines and in patient-derived tumor xenografts.

物理化学性质&存储条件

分子量	581.98
分子式	C28H23ClF3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-chloro-3-(2-((4-(methylcarbamoyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)yl)phenyl)-4(trifluoromethyl)picolinamide

参考文献

1. Murone M, et al. Mol Cancer Ther. 2016 Oct;15(10):2334-2343.

2. Murone M, et al. Mol Cancer Ther. 2017 May 3. pii: molcanther.0889.2016.

Debio 0617B (Debio 0617B;Debio-0617B)

生物&药学活性

物理化学性质&存储条件

参考文献

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Debio 0617B (Debio 0617B;Debio-0617B)

生物&药学活性

物理化学性质&存储条件

参考文献

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