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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-AS1517499
AS1517499

Chemical Structure : AS1517499

CAS No.: 919486-40-1

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AS1517499 (AS-1517499;AS 1517499)

货号: PC-42210Not For Human Use, Lab Use Only.

AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.

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10 mg ￥1580 In stock
25 mg ￥2880 In stock
50 mg ￥4680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay.
AS1517499 inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12.
AS1517499 completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.

物理化学性质&存储条件

分子量 397.8581
分子式 C20H20ClN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

5-Pyrimidinecarboxamide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-

参考文献

1. Nagashima S, et al. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55.

2. Chiba Y, et al. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24.

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